Flomax contains two what is deca durabolin components having bronchodilator activity.What is deca durabolin when inhaled ipratropium bromide is due mainly to local rather than systemic anticholinergic effects.In patients with bronchospasm associated with chronic obstructive pulmonary disease (chronic bronchitis and emphysema), significant improvement in lung function (increase in forced expiratory volume in 1 second (FEV1) and the average space velocity forced expiratory 15% or more) was observed in 15 minutes, the maximal effect was achieved after 1-2 hours and lasted in most patients to 6 hours after administration.Ipratropium bromide does not adversely affect the secretion of mucus in the airways, mucociliary clearance and gas exchange.
What is deca durabolin relaxes bronchial smooth muscle and blood vessels and prevents the development of bronchospastic reactions, caused by histamine, methacholine, cold air and allergen (immediate hypersensitivity reaction). Immediately after administration fenoterol blocks the release of mediators of inflammation and bronchial mast cells. Furthermore, when using fenoterol higher doses noted increased mucociliary clearance.
Beta-adrenergic effect of the drug on cardiac activity, such as increased frequency and severity of heart rate caused by a vascular effect fenoterol, beta2-adrenergic stimulation of the heart, and at doses exceeding therapeutic, beta1-adrenoceptor stimulation. Tremor is the most frequent undesirable effect of using beta-agon ists.
In a joint application of the two active substances bronchodilation effect is achieved by acting on different pharmacological targets. These substances complement each other, resulting in enhanced antispasmodic effect on bronchial muscles and provides greater breadth of therapeutic action in bronchopulmonary diseases involving airway constriction. The complementary action is such that in order to achieve the desired effect required a lower dose of the beta-adrenergic component, which allows individual selection of an effective dose of the substantial absence of side effects.
prevention and symptomatic treatment of chronic obstructive diseases of the airways with reversible bronchospasm such as bronchial asthma and, especially, chronic obstructive lung disease (chronic obstructive bronchitis and emphysema).
Hypertrophic obstructive cardiomyopathy, tachyarrhythmia. Hypersensitivity to fenoterolu hydrobromide or atropine drugs or other components of the drug.
Precautions: angle-closure glaucoma, coronary insufficiency, arterial hypertension, diabetes mellitus, recent myocardial infarction, severe organic heart disease and blood vessels, hyperthyroidism, pheochromocytoma, prostatic hypertrophy, bladder neck obstruction, cystic fibrosis, pregnancy, breastfeeding, children under 6 years.
Pregnancy and lactation
should consider the possibility of an inhibitory effect on Berodual uterine activity.
fenoterol hydrobromide passes into breast milk. Data showing that ipratropium bromide passes into breast milk has not been received. However, given that many drugs penetrate into breast milk, it should be used with caution in nursing mothers Flomax.
Dosage and administration
The dosage should be individualized. During therapy requires medical supervision. The recommended dose:
Adults (including the elderly) and adolescents over 12 years: Acute asthma attacks with mild to moderate attacks, in many cases, it is recommended 1 ml (20 drops). In particularly severe cases, such as patients who are in intensive care units, the ineffectiveness doses set forth above may require higher doses, and 2.5 ml (50 drops). In severe cases, may use under medical supervision maximum dose reaching 4.0 ml (80 drops).
A course of treatment is prolonged and
if necessary re-application for each administration, 1 – 2 ml (20 – 40 drops) to 4 times per day. The maximum daily dose – 8 ml.
In the case of moderate bronchospasm or as an aid in implementing ventilation recommended dose, the lower level of which is 0.5 ml (10 drops).
In children aged 6-12 years:
Acute asthma attacks
in many cases, for quick relief of symptoms is recommended 0.5 -1 ml (10-20 drops).
In severe cases, may require higher doses of up to 2 ml (40 drops).
In severe cases, can be applied (for under medical supervision) with a maximum dose that reaches 3.0 ml (60 drops).
Term and long-term treatment
, if necessary re-application is used for each injection of 0.5 mL -1 (10 – 20 drops) up to 4 times per day. The maximum daily dose – 4 ml.
In the moderate cases of bronchospasm or as an aid in implementing ventilation recommended dose – 0.5 ml (10 drops).
In children younger than 6 years (body weight of less than 22 kg):
Due to the fact that the application of the drug in this age group, the information is limited, the following are recommended dosage (only under medical supervision):
About 25 ug of ipratropium bromide and fenoterol hydrobromide 50 mg per kg body weight (per dose) = 0.5 ml (10 drops) up to 3 times a day. The maximum daily dose of 1.5 ml.
Treatment should usually start with the lowest recommended dose.
The recommended dose must be reconstituted with saline to a final volume of 4.3 ml, and applied (totally) using a nebulizer.
Beroduapa solution for what is deca durabolin should not divorce distilled water.
Dilution solution must be carried out every time before use; remnants of the diluted solution should be destroyed.
Dosing may depend on the method and type of the what is deca durabolin nebulizer. The duration of what is deca durabolin can be controlled by spending diluted volume.
Beroduapa what is deca durabolin solution can be applied using various commercial models nebulizers. In those cases where there is a wall oxygen, the solution is best applied 6-8 liters per minute at flow rate.
If necessary, the use of this dose can be repeated at intervals of not less than 4 hours.
The most common adverse effects Berodual a fine tremor of skeletal muscles, nervousness, dry mouth and changes in taste; less common headache, dizziness, tachycardia and palpitations, especially in patients with confounding factors.
The consequence of treatment may be severe hypokalemia.
In the treatment of Berodual may develop a cough, respiratory tract irritation, less occurrence of paradoxical bronchospasm.
Application Berodual can cause nausea, vomiting, sweating, a feeling of general weakness, myalgia or muscle cramps. In rare cases decrease in diastolic blood pressure, increase in systolic blood pressure, arrhythmias, changes of mentality.
Sometimes there reversible eye accommodation disorders, motility disorders of the gastrointestinal tract (especially in patients with cystic fibrosis), and urinary retention.
Eye contact – mydriasis, increased intraocular pressure (pain or discomfort in the eyeball, blurred vision, feeling ghosting or color spots before the eyes, conjunctival hyperemia).
In rare cases, skin reactions or allergic reactions such as skin rash, angioedema swelling of the tongue, lips and face, urticaria.
Overdose symptoms are usually associated primarily with the effect of fenoterol.
There may be symptoms associated with excessive stimulation of beta-adrenergic receptors. Most likely the appearance of tachycardia, palpitations, tremor of fingers, high blood pressure, lowering blood pressure, increasing the difference between systolic and diastolic blood pressure, arrhythmia, angina, arrhythmia and feelings flares, enhance airflow obstruction.
Symptoms of overdose due to ipratropium bromide (such as dry mouth, accommodation disturbances Eye), are mild and transient, due to a wide range of therapeutic doses of this drug and its local application.
is recommended the use of sedatives, tranquilizers, in severe cases – intensive care.
As a specific antidote is possible to use beta-adrenoceptor blockers, preferably beta1-selective blocker. However, in patients with asthma or COPD should be considered an opportunity to strengthen the bronchial obstruction under the influence of beta-blockers and carefully select their dose.
Interactions with other drugs
Beta-adrenergic and anticholinergics, xanthine derivatives (eg, theophylline) may enhance the effect of bronchodilator Berodual. Concomitant use of other beta-adrenomimeticheskih funds, anticholinergics, and systemic effects of xanthine derivatives (eg, theophylline) may lead to increased side effects.
Possibly a significant weakening of bronchodilator action Berodual while the appointment of beta-blockers.
Hypokalemia associated with the use of beta-agonists may be enhanced by the simultaneous appointment of xanthine derivatives, steroids and diuretics. This fact should be given special attention in the treatment of patients with severe obstructive airways disease.
Hypokalemia may increase the risk of arrhythmias in patients receiving digoxin. Additionally, hypoxia may exacerbate the negative effect of hypokalemia on cardiac rhythm. In such cases it is advisable to carry out monitoring of the level of potassium in the blood serum.
It should be used with caution in beta-adrenergic agents patients receiving monoamine oxidase inhibitors and tricyclic antidepressants, since these drugs can increase the effects of beta-adrenergic agents.
what is deca durabolin of halogenated hydrocarbon anesthetics such as halothane, trichlorethylene and enflurane may increase the effect of beta-adrenergic agents on the cardiovascular system.
The combined use of Berodual kromoglitsievoy with acid and / or corticosteroids increases the effectiveness of therapy.
in the case of unexpected rapid amplification of dyspnea (difficulty breathing) should immediately consult a doctor.
- in patients suffering from bronchial asthma or mild and moderate chronic obstructive pulmonary disease (COPD), symptomatic treatment may be preferable to regular use
- in patients with bronchial asthma or severe COPD should be mindful of the need for strengthening or anti-inflammatory therapy to control airway inflammation and the disease process.
Regular use of increasing doses of products containing beta2-adrenoceptor agonists, such as Flomax, for the relief of bronchial obstruction can cause uncontrolled deterioration of the disease course. In the event the bronchial obstruction simply increasing the dose of beta 2-agonists, including Berodual longer recommended for a long time not only justified, but also dangerous. To prevent life-threatening deterioration of disease should consider reviewing the patient’s treatment plan, and adequate anti-inflammatory therapy with inhaled corticosteroids.
Other sympathomimetic bronchodilators should be administered simultaneously with Berodual only under medical supervision.
Patients should be instructed on the proper use of inhaled Berodual solution. It is necessary to take precautions to prevent contact with eyes. It is recommended that the solution is used with a nebulizer, inhaled through a mouthpiece. In the absence of a mouthpiece should be used tight to the face mask. Particular care should be concerned about eye protection, patients predisposed to the development of glaucoma.
Shortly before giving birth should stop taking the drug, due to the possibility of weakening labor fenoterol. buy anabolic steroids online bruce lee’s workout anabolic steroids online uk