injectable deca durabolin for sale

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Pharmacodynamics injectable deca durabolin for sale hydrobromide -. Selective beta2-adrenergic stimulant stimulation of .beta.1-adrenergic receptors occurs when using the drug in higher doses. Binding β2-adrenoreceptor activates adenylate cyclase through a stimulatory GS-protein formation, followed by an increase of cAMP, which in turn activates protein kinase A which then phosphorylates target proteins in the cells of smooth muscles. This in turn leads to the phosphorylation of myosin light chain kinase, and inhibition of hydrolysis fosfoinozina kaltsiyaktiviruemyh rapid opening of potassium channels.

Thus, injectable deca durabolin for sale causes relaxation of smooth muscles of the bronchi and blood vessels, as well as protects it from bronchoconstrictor exemestane for sale such factors as histamine, methacholine, cold air and allergen (immediate type reactions). After taking the drug inhibited mast cells release mediators of inflammation. Furthermore, after receiving high doses injectable deca durabolin for sale been increasing mucociliary transport. injectable deca durabolin for sale also exhibits the properties of the respiratory stimulant.

Higher concentrations of the drug in the blood plasma, often achieved after oral administration and especially following intravenous administration, the ability to inhibit uterine contractility. When high doses of the drug are also observed effects on metabolic level: Lipolysis, glycogenolysis, hyperglycemia and hypokalemia (the latter is due to the increased absorption of K + skeletal muscles).

β-Adrenergic effects on the level of the heart muscle, such as increased heart rate and increased myocardial contractility, explained injectable deca durabolin for salea effect on blood vessels, stimulation of β2-adrenergic receptors, and (while taking the drug at doses above the therapeutic range) stimulation of β1-adrenergic receptors. Frequently observed effect agonists β-adrenoceptor is tremor. In contrast to the action on the smooth muscles of the bronchi systemic effects of β-adrenergic receptor agonists are associated with the development of tolerance.

injectable deca durabolin for sale alerts and quickly relieves bronchospasm different genesis. Onset of action after inhalation -. 5 minutes, maximum – 30-90 mi n, the length of -. 3-6 hours.
There is no sufficient data on the effect of injectable deca durabolin for sale hydrobromide metabolism in diabetes.

Pharmacokinetics
Depending on the method of inhalation and the system used by the inhalation of about 10-30% of active ingredient released from the aerosol preparation clomiphene pct after inhalation, reaches the lower respiratory tract, and the remainder is deposited in the upper airways and is swallowed. As a result, a certain amount of inhaled injectable deca durabolin for sale enters the gastrointestinal tract. After inhalation of a single dose of the drug Berotek extent of absorption is 17% of the administered dose. Suction is biphasic – 30% of injectable deca durabolin for sale hydrobromide is rapidly absorbed from the half-life of 11 minutes, and 70% is absorbed slowly with half-life of 120 minutes.

There is no correlation between injectable deca durabolin for sale plasma concentrations reached after inhalation and pharmacodynamic curve “time – effect”. Prolonged bronchodilatory effect after inhalation of the drug that is comparable to corresponding effects achieved after intravenous administration, is not supported by high concentrations of active agent in the systemic circulation. After oral administration absorbed about 60% of injectable deca durabolin for sale hydrobromide. The time to reach maximum concentration in plasma TC max – 2 hours. Connection with the plasma protein-40-55%. It is metabolized in the liver. Excreted by the kidneys and the bile as inactive sulfate conjugates. After 24 hours 60% of the inputted I / dose and 35% of an oral dose is excreted in the proportion of active substance mochoy.Eta biotransformation due to “first pass effect” through the liver, resulting in drug bioavailability after oral administration of drops to about 1.5%. This explains the fact that the amount of swallowed drug had virtually no impact on the level of the active substance in the blood plasma is reached after inhalation.

In parenteral administration, injectable deca durabolin for sale hydrobromide respectively output three-phase model with half-lives -. 0.42 min, 14.3 min and 3.2 h injectable deca durabolin for sale hydrobromide biotransformation occurs only in humans by conjugation with sulphates predominantly in the intestinal wall.

injectable deca durabolin for sale hydrobromide can pass unaltered through the placental barrier and passes into breast milk.

Indications

  • Relief of asthma attacks of asthma.
  • Preventing asthma attacks as a result of physical exertion.
  • Symptomatic treatment of bronchial asthma and other conditions with reversible narrowing of the airways (eg, chronic obstructive bronchitis). In patients with asthma and chronic obstructive pulmonary disease, responsible for steroids, should consider the need for anti-inflammatory treatment.
  • As bronchodilator agents before inhalation of other drugs (antibiotics, mucolytics, corticosteroids)
  • Holding acting bronchodilator test in the study of respiratory function.

Contraindications:
Hypersensitivity kinjectable deca durabolin for saleu hydrobromide or to the other ingredients of the drug. Hypertrophic obstructive cardiomyopathy, tachyarrhythmia.

Precautions: hyperthyroidism, hypotension, hypertension, intestinal, hypokalemia, diabetes mellitus, recent myocardial infarction, severe diseases of the cardiovascular system, pheochromocytoma.

Pregnancy and lactation
Preclinical studies in conjunction with the existing clinical experience with the drug suggests that it does not cause any adverse effects during pregnancy. However, caution should be exercised in respect of normal use of drugs during pregnancy (especially in the first third of it). We should not forget that injectable deca durabolin for sale inhibit uterine function.
Preclinical studies have shown that injectable deca durabolin for sale passes into breast milk. Safety drug lactation period has not yet been established.

Dosing and Administration
Inhalation.
(20 drops = 1 ml)
(1 drop = 50 mcg injectable deca durabolin for sale hydrobromide)

Doses should be adjusted according to individual patient needs; In addition, during the treatment the patient should be under medical supervision.
We recommend the following dosing regimen Unless otherwise indicated:

Adults (including elderly patients) and adolescents over 12 years:

Attacks of asthma:
0.5 ml (10 drops = 0.5 mg injectable deca durabolin for sale hydrobromide) is in many cases sufficient for the immediate relief of symptoms,
in severe cases, when the majority of patients requiring emergency medical care, may require higher doses of 1 to 1 25 ml (20-25 drops = 1-1.25 mg injectable deca durabolin for sale hydrobromide),
in extremely severe cases, can be administered under medical supervision to 2 ml (40 drops = 2 mg of injectable deca durabolin for sale hydrobromide);

Prevention of asthma attacks due to physical stress:
0.5 ml (10 drops = 0.5 mg of injectable deca durabolin for sale hydrobromide) to receive up to 4 times a day;

Bronchial asthma and other conditions with reversible airway narrowing:
if necessary, re-administration of the drug take 0.5 ml (10 drops = 0.5 mg injectable deca durabolin for sale hydrobromide) up to 4 times a day;

Children 6 to 12 years (about 22-36 kg body weight):

Asthma attacks:
0.25-0.5 ml (5-10 drops = 0.25-0.5 mg injectable deca durabolin for sale hydrobromide) is in many cases sufficient for the immediate relief of symptoms,
in severe cases may require higher doses of up to 1 ml (20 drops = 1 mg of injectable deca durabolin for sale hydrobromide),
in extremely severe cases, can be administered under medical supervision to 1.5 ml (30 drops = 1.5 mg injectable deca durabolin for sale hydrobromide);

Prevention of asthma attacks due to physical stress:
0.5 ml (10 drops = 0.5 mg of injectable deca durabolin for sale hydrobromide) to receive up to 4 times a day;

Bronchial asthma and other conditions with reversible airway narrowing:
if necessary, re-administration of the drug take 0.5 ml (10 drops = 0.5 mg injectable deca durabolin for sale hydrobromide) up to 4 times a day;

Children up to 6 years (weighing less than 22 kg):
due to the limited information in this age group, treatment is carried out only under the supervision of a physician to prescribe the following dose: 50 mg / kg at the reception (5-20 drops = 0, 1.25 mg) 3 times a day.

Treatment is started generally with the lowest recommended dose.

The recommended dose is diluted with physiological saline to a final volume of 3.4 ml was sprayed and inhaled until complete consumption of the resulting dilution. Berotek 0.1% solution should not be diluted with distilled water.

The solution was diluted anew each time before use; remnants of the diluted solution is discarded.

Dosage regimen may depend on the method of the inhaler and the inhalation characteristics. The duration of inhalation can control the volume of dilution.

Berotek 0.1% solution may be applied using the commercially available inhalation devices. In the presence of oxygen-breathing apparatus inhaled best solution in 6.8 L / min flow rate.

Berotek 0.1% solution may be inhaled simultaneously with approved choline and mucolytic agents. This is particularly true of drugs Atrovent ® , mukozolvan ® and bizolvon ® in the form of solutions for inhalation, and / or in aerosol containers with a metering valve.

If necessary, subsequent inhalation conducted at intervals of not less than 4 hours.

Side effects:
For common adverse effects of the drug Berotek 0.1% solution are fine tremor of skeletal muscles and nervousness, headache, dizziness, tachycardia, and palpitation. In rare cases, pain may be observed stenokardicheskie, diastolic pressure, systolic pressure, heart arrhythmias, especially when high doses of the drug.

Treatment with agonists of β-adrenergic receptors can lead to severe hypokalemia.
As with the inhalation of other drugs, there may be a cough, local irritation and the smaller than usual, the probability of paradoxical bronchoconstriction.
As with other β-adrenomimeticheskih means may be place nausea, vomiting, sweating, weakness and myalgia and muscle cramps, hyperglycemia, weakening motility of the upper urinary tract, tolerant.

There are rare reports of skin or allergic reactions, especially in patients with hypersensitivity.

Overdose

Symptoms
Expected overdosage symptoms are the same as in the over-stimulation of adrenergic β-receptors, including known, but excessively enhanced pharmacological effects (for example, some of the symptoms listed in the “side effects” section); the most notable of these are tachycardia, palpitation, tremor, hypertension, hypotension, increased pulse pressure, anginal pain, cardiac arrhythmias, and facial flushing.

Treatment
is usually given sedatives, tranquilizers, in severe cases, is carried out intensive sympathomimetic therapy. As specific antidotes can be administered adrenergic blockers, β-receptor (preferably selective blockers β1-adrenergic receptors); At the same time, we should consider the possibility of strengthening of bronchial obstruction and carefully choose the dose of these drugs in patients suffering from bronchial asthma.

Interaction with other drugs
β-adrenergic agents, anticholinergics, xanthine derivatives (such as theophylline), cromolyn sodium, corticosteroids and diuretics may increase the effects and side effects of injectable deca durabolin for sale.
A significant reduction in bronchodilation may occur during the simultaneous application fenoterala blockers and β- adrenergic receptor.
agonists of β-adrenergic receptors should be used with caution in patients receiving MAO inhibitors or tricyclic antidepressants, which are able to enhance the effect of β-adrenergic agonists.

Inhalation anesthetics fluorocarbon such as halothane, halothane, enflurane and trichlorethylene, may increase the likelihood of action of β-adrenoceptor agonists at the level of the cardiovascular system.Halothane sensitizes the myocardium to the action of injectable deca durabolin for sale, promotes the development of arrhythmias. Co-administration of bronchodilators with a similar mechanism of action results in an additive effect and the phenomena of overdose.

Cautions
Patients with diabetes mellitus during treatment should be carried out regular monitoring of glucose in plasma.
Other sympathomimetic bronchodilators can be used together with the drug Berotek 0.1% solution only under medical supervision.
In acute, rapidly evolving dyspnoea (difficulty breathing), you should immediately consult with your doctor.

Long-term use:

  • treatments as needed (symptom-oriented) can be preferably regular application of a drug;
  • Patients should be screened for carrying out additional or more intensive anti-inflammatory therapy (eg, inhaled corticosteroids) to control airway inflammation and to prevent long-term exacerbations of asthma.

In the event the bronchial obstruction is deemed unacceptable, and may even be risky simply increasing acceptance agonists β2-adrenergic receptors contained in such formulations as Berotek 0.1% solution, over the recommended dose and the recommended duration of use. Receiving high doses β2-adrenergic agonists contained in such formulations as Berotek 0.1% solution, in order to control symptoms of bronchial obstruction can cause uncontrolled deterioration of the disease course. In such a situation it is necessary to revise the treatment plan and, in particular, the adequacy of anti-inflammatory therapy.
In the treatment of β2-adrenergic agonists may develop severe hypokalemia. Particular caution should be exercised in severe asthma as this effect may be enhanced by concomitant use of xanthine derivatives, glucocorticosteroids and diuretics. Furthermore, during hypoxia may increase the effect of hypokalemia on cardiac rhythm. In such situations, we recommend regular monitoring of potassium serum levels.

Product Form
In 20 ml, 40 ml or 100 ml glass vials of amber glass, polyethylene dropper and a polypropylene screw cap. Bottle with instruction placed in a cardboard box. clenbuterol vaegttab