Pharmacological action deca durabolin side effects fat-soluble derivative of thiamine. Thiamin is converted into an active and thiamine pyrophosphate as a coenzyme, it is included in piruvatdekarboksilaznogo, alpha ketoglutaratdekarboksilaznogo complexes which are involved in the oxidative decarboxylation of pyruvate and alpha-ketoglutaric acid; transketolase – an enzyme of the pentose phosphate shunt.
The absorption – high, throughout the small intestine. Before suction is released from the bound state of digestive enzymes. After 15 min, detected in blood at 30 minutes – in other tissues.. The relatively low concentration of blood circulates predominantly free thiamine, in erythrocytes and leukocytes in the plasma with – its phosphoric esters. Phosphorylation occurs in the liver. The most active phosphoric ester is tiamindifosfata with a co-enzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, and spleen. 1/2 of the total amount contained in striated muscles and the myocardium, and about 40% in the internal organs.Displayed through the intestines and kidneys.
Deficiency of B 1 confirmed by clinical and biochemical studies, developing on the background:
- insufficient and malnutrition (beriberi);
- parenteral nutrition for a long time, hemodialysis;
- alcoholism (alcoholic cardiomyopathy, Wernicke’s encephalopathy, Korsakoff’s syndrome);
- an increased need for vitamin B 1 .
Polyneuropathy due to deficiency of vitamin B 1 . Typical symptoms of this deficiency are nevrologichenskie disorders as neuropathy with sensory impairments (pain, tingling, numbness in the upper and lower extremities).
Individual hypersensitivity to the drug, sucrose deficit / isomaltose, fructose intolerance glucose-galactose malabsorption, 1 pregnancy, children’s age.
Pregnancy and lactation
Pregnancy is a contraindication for deca durabolin side effects the use of the drug.
Dosage and administration
for the treatment of deficiency of vitamin B 1 :. 1 times a day 1 tablet
for the treatment of polyneuropathy caused by a deficiency of vitamin B 1 : initial dose of 1 tablet 2 times a day for 3 weeks, followed by 1 tablet daily.
Duration treatment depends on its efficiency and is determined by your doctor.
The tablets are not liquid, squeezed small amounts of water.
Allergic reactions: angioedema, urticaria, pruritus.
is not observed.
Interaction with other drugs
Thiamine weakens the effect of depolarizing muscle relaxant (suxamethonium iodide, etc.), Fluorouracil inhibited.
The ethanol slows the rate of absorption following oral administration of thiamine.
In the elderly adverse reactions other than those mentioned above, have been reported.
It is not recommended to take a double dose of the drug, if the previous reception was missing.
When Wernicke encephalopathy should precede the introduction of dextrose intake of thiamine.
Effects on ability to drive vehicles and mechanisms
No data on the effect of the drug on the ability to drive vehicles and mechanisms applied in therapeutic doses.
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