Pharmacodynamics bactericidal antibiotic from the group of biosynthetic “natural” deca durabolin for sales. It inhibits synthesis of cell walls of microorganisms. It is active against gram-positive pathogens: Staphylococcus spp. (neobrazuyuschie deca durabolin for salease), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces spp .; Gram-negative organisms: Neisseria gonorrhoeae, Neisseria meningitidis, and Spirochaetes class family, including Treponema spp. Not effective against most gram-negative bacteria, Rickettsia spp., Protozoa. By the action of the drug resistant strains of microorganisms penitsillinazoobrazuyuschie.
Pharmacokinetics maximum concentration (TC max ) by intramuscular administration – 20-30 minutes. Communication with plasma proteins – 60%. Into the organs, tissues and biological fluids except liquor, eyes and prostate tissue, penetrates the blood-brain barrier (BBB) in inflammation meningeal membranes. Excreted by the kidneys unchanged. The half-life (T?) Of 30-60 minutes in renal failure – 4-10 hours or more.
The infectious-inflammatory diseases caused by susceptible pathogens:
- Respiratory : community-acquired pneumonia, empyema, bronchitis;
- Upper respiratory tract;
- genitourinary system: pyelonephritis, pyelitis, cystitis, urethritis, cervicitis;
- bile ducts : cholangitis, cholecystitis;
- skin and soft tissues : erysipelas, impetigo, secondarily infected dermatoses, wound infection;
- Eye disorders : blennophthalmia, corneal ulcer;
- sepsis, septic endocarditis (acute and subacute)
- gonorrhea, syphilis;
- diphtheria; scarlet fever; actinomycosis; anthrax.
Hypersensitivity, including to other deca durabolin for sales, cephalosporins.
Allergic diseases (asthma, hay fever), renal insufficiency.
Pregnancy and lactation
Pregnancy is possible if the expected benefit to the mother outweighs the potential risk to the fetus. If necessary, use during lactation should stop breastfeeding.
Dosage and administration
intramuscularly, subcutaneously. Intramuscularly at srednetyazhёlom during infections of the upper and lower respiratory tract, urinary and biliary tract, soft tissue infections, and others. -.. 2.5-5 million units in 4 administrations per day Daily dose for children under 1 year – 50000-100000 U / kg, over 1 year – 50,000 units / kg; if necessary – 200000-300000 U / kg; for “life” readings – an increase to 500,000 units / kg. . The multiplicity of introduction – 4-6 times a day subcutaneously for injecting infiltrates a concentration 100000-200000 units in 1 ml of 0.25-0.5% procaine solution. In diseases of the eye : eye drops at a concentration of 20,000-100,000 units in 1 mL 0 9% sodium chloride solution or distilled water, sodium, 1 to 2 drops 6-8 times a day. The duration of drug treatment depending on the form and severity of the disease-7-10 days.
A method for preparing solutions
solution formulation for intramuscular injection is prepared immediately prior to administration, the contents of the vial by adding 3.1 ml of water for injection or 0.9% sodium chloride or 0.5% solution of procaine.
Dilution procaine benzyldeca durabolin for sale in solution turbidity can be observed solution due to the formation of crystals of procaine deca durabolin for sale G, which is not an obstacle for intramuscular and subcutaneous administration. The solutions were used immediately after preparation, avoiding the addition thereto of other drugs.
A solution for topical ophthalmic use should be prepared ex tempore: the contents of the vial diluted in 0.9% chloride, distilled water or sodium chloride – 500 000 -25 5 IU per ml, 1,000,000 ED 10-50 ml, respectively.
Side effects: Allergic reaction : pyrexia, urticaria, rash, rash on the mucous membranes, arthralgia, eosinophilia, angioedema, interstitial nephritis, bronchospasm; rarely – anaphylactic shock. At the beginning of treatment (particularly in the treatment of congenital syphilis), rarely – fever, chills, sweating, exacerbation, Jarisch-Herxheimer. On the part of the cardiovascular system : reducing emissions of myocardial arrhythmia fraction, heart failure, chronic heart failure (ie. . to the introduction of large doses may cause hypernatremia). Local reactions : pain and induration at the site of intramuscular administration Others : long-term use goiter, superinfection development.
Overdose symptoms : convulsions, disturbance of consciousness. Treatment : removal of the drug, symptomatic therapy.
The interaction with other drugs
Bactericidal antibiotics (including cephalosporins, vancomycin, aminoglycosides rifampicin) have a synergistic effect; bacteriostatic (including macrolides, chloramphenicol, lincosamides, tetracyclines) – Increases the antagonistic effectiveness of indirect anticoagulants (suppressing the intestinal microflora reduces prothrombin index); reduces the effectiveness of oral contraceptive drugs, metabolism which is formed of p-aminobenzoic acid -. risk of bleeding “breakthrough”
diuretics, allopurinol, blockers of tubular secretion, phenylbutazone, nonsteroidal anti-inflammatory drugs, lowering the tubular secretion, increase the concentration of benzyldeca durabolin for sale.
Allopurinol increases the risk of allergic reactions (skin rash).
If after 2-3 days (up to 5 days) after initiation of the drug effect is not observed, it is necessary to move to the use of other antibiotics or combination therapies. It is advisable during long-term treatment of benzyldeca durabolin for sale appoint B vitamins, if necessary in connection with the possibility of fungal infections – antifungals. Please note that the use of insufficient doses or too early discontinuation of treatment often leads to the emergence of resistant strains of pathogens.
For information on the effect of the drug on the ability to drive and no other mechanisms. However, given the possible side effects to the cardiovascular system, care must be taken when engaging in such activities.
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Powder for solution for intramuscular and subcutaneous administration of 500,000 units, 1,000,000 units in bottles with a capacity of 10 ml.
1 bottle with instruction on use are placed in the pack.
10 vials along with instructions for use are placed in a box made of cardboard boxed.
For the hospital: 50 vials of 5 and instructions for use are placed in a box made of cardboard boxed.
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