The pharmacological properties of antiepileptic drugs, has almost no hypnotic action.
Increases GABAergic inhibitory effect of the central nervous system, especially in the thalamus, the ascending activating reticular formation of the brain stem at the level of neurons. By reducing the permeability of the nerve fiber membranes for Na +, reduces the spread of the pulse from the source of epileptic activity.The effect occurs within 20-60 minutes after oral administration.
Rapidly metabolized in the body, releasing phenobarbital, which has an antiepileptic effect. Relationship to plasma proteins – weak. A high concentration in the brain, liver and kidneys. It penetrates through the blood-tissue barrier and into breast milk. The half-life – 3-4 days. Excreted by the kidneys as intact or in the form of metabolites.
Epilepsy various origins, generalized and partial seizures, epileptic syndrome. Focal seizures, including Jacksonian epilepsy, Kozhevnikov epilepsy. Small seizures (non-convulsive).
Hypersensitivity, hepatic failure, renal failure, cardiac insufficiency II-III degree, porphyria, anemia, asthma, respiratory insufficiency, diabetes mellitus, hyperthyroidism, adrenal insufficiency, hyperkinesis, depression (with suicide attempts), children under 3 years, pregnancy (I and III trimester), lactation.
Dosing and Administration
Inside, after a meal, 3 times a day. Dosage and individual appointed by the doctor. Adults: Single dose – 0,1-0,15-0,2 g, maximum single dose – 0.3 grams, the maximum daily dose – 0.8 of a continuous course of treatment and long-term, not less than 2 years. children: For children 3-6 years single dose – 0.025-0.05 g daily – 0.1-0.15 g; 7-10 years single – 0.05-0.1 grams daily – 0.15-0.3 g; 11-14 years, single – 0.1 grams daily – 0.3-0.4 g; the maximum single dose for older children – 0.15 g; the maximum daily – 0.45 g
Side effects of
addiction, drug addiction, “cancellation” syndrome, bronchospasm, reduction in blood pressure, thrombocytopenia, anemia, thrombophlebitis, drowsiness, lethargy, confusion, headache, loss of appetite, difficulty in speech, ataxia, nystagmus, mental retardation reactions; allergic reactions.
Overdose symptoms: depression of the central nervous system functions (drowsiness, blurred vision, ataxia, dysarthria, nystagmus) up to coma, respiratory center depression, lower blood pressure, renal dysfunction, headache, severe fatigue, increase or decrease in body temperature, agitation, pupillary constriction, tachy or bradycardia, cyanosis, hemorrhage in the pressure field, pulmonary edema. In chronic intoxication – irritability, weakening of the capacity for critical evaluation, sleep disturbances, confusion. Treatment: gastric lavage, activated charcoal, symptomatic therapy.
Interaction with other drugs
Enhances the effect of narcotic analgesics, general anesthetics, antipsychotics, tranquilizers, tricyclic antidepressants, ethanol, hypnotics, reduces – paracetamol, anticoagulants, tetracyclines, griseofulvin, glucocorticoids, mineralocorticoids, cardiac glycosides, quinidine, vitamin D, xanthine .
When moving to benzonalom treatment in patients previously treated with other barbiturates may sleep disturbance which persists appointment to night phenobarbital (0.05-0.1) g or other hypnotics. Currently, the treatment of patients with epilepsy begins with others. Antiepileptic drugs (valproic acid, carbamazepine, etc..) With less pronounced side effects. deca durabolin cycle appoint, if these means are not effective, often as part of combination therapy.
During treatment, do not drink alcoholic beverages.
It is necessary to refrain from potentially hazardous activities that require high concentration.
Product form .
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Tablets 50 mg: 10 tablets in blisters. . 3 or 5, the contour of cellular packaging with instructions for use in paper cartons
Tablets 100 mg: 10 tablets in blisters. 5 contour cell packages with instructions for use in paper cartons. steroiden kaufen
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